C127

CNQX

≥98% (HPLC), solid

• Synonym(s): 6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065
• Empirical Formula (Hill Notation): C₉H₄N₄O₄
• CAS Number: 115066-14-3
• Molecular Weight: 232.15
• MDL number: MFCD00069232
• UNSPSC Code: 12352200
• PubChem Substance ID: 24892392
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: yellow
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• SMILES string: [O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N
• InChI: 1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
• InChI key: RPXVIAFEQBNEAX-UHFFFAOYSA-N
• Gene Information: rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409)

Description

Application

CNQX has been used:

• as an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate blocker to study its effects on cytoneme formation in pluripotent embryonic stem cells (pESCs)
• glutamate blocker to reduce the synaptic input during current-clamp recordings in central antennal lobe neurons
• as a non-N-methyl-D-aspartate (NMDA) receptor blocker to study its effects on the heart rate in rats

Biochem/physiol Actions

Potent, competitive AMPA/kainate glutamate receptor antagonist.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves