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C4428

Sigma-Aldrich

Cathepsin G from human leukocytes

lyophilized powder, ≥60 units/mg protein (Bradford)

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10 G
₩201,275

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10 G
₩201,275

About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

₩201,275


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biological source

human leucocytes

Quality Level

form

lyophilized powder

specific activity

≥60 units/mg protein (Bradford)

mol wt

23-30 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CTSG(1511)

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This Item
287784337064196118
assay

99%

assay

99%

assay

99%

assay

99%

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

200

refractive index

n20/D 1.415 (lit.)

refractive index

-

refractive index

n20/D 1.406 (lit.)

refractive index

-

density

1.45 g/mL at 25 °C (lit.)

density

-

density

1.226 g/mL at 25 °C (lit.)

density

-

bp

160 °C (lit.)

bp

101-102 °C/1 mmHg (lit.)

bp

102 °C (lit.)

bp

-

functional group

fluoro

functional group

hydroxyl

functional group

fluoro, phenoxy

functional group

-

General description

Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes.[1] It belongs to the family of serine proteases.[2] Cathepsin G is a glycoprotein, which contains 1% carbohydrate.[1] The gene is located on human chromosome 14q12.[3]

Application

Cathepsin G from human leukocytes has been used to determine protease sensitivity.[4] It has also been used for the stimulation and staining of dendritic cells and macrophage.[5]

Biochem/physiol Actions

Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism.[1] Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors.[6] It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells.[2] Cathepsin G is associated with autoimmunity and cancer.[7] It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.[8]
Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.

Unit Definition

One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.

Physical form

Lyophilized from 0.5 M pyridinium acetate, pH 5.3.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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