C6737

Chondroitin sulfate sodium salt from bovine cartilage

98-102% (CPC, titration)

• CAS Number: 9082-07-9
• UNSPSC Code: 12352201
• PubChem Substance ID: 24892886
• NACRES: NA.25

Properties

• biological source: bovine cartilage
• Quality Level: 200
• grade: standard (for CPC (cetylpyridinium chloride) titration)
• Assay: 98-102% (CPC, titration)
• form: powder
• optical activity: [α]20/D -30 to -20 °, c = 5% (w/v) in water
• impurities: <10.0% water (Karl Fischer)
• color: white to off-white
• solubility: H₂O: soluble 50 mg/mL, clear to hazy, colorless to faintly yellow
• cation traces: Na: 7.4-8.8% (anhydrous)
• storage temp.: 2-8°C
• SMILES string: [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]2O[C@@H]([C@H](O)[C@@H](O)[C@@H]2O)C(O)=O
• InChI: 1S/C14H23NO15S.Na/c1-3(17)15-5-10(9(30-31(24,25)26)4(2-16)27-13(5)23)28-14-8(20)6(18)7(19)11(29-14)12(21)22;/h4-11,13-14,16,18-20,23H,2H2,1H3,(H,15,17)(H,21,22)(H,24,25,26);/q;+1/p-1/t4-,5-,6-,7-,8+,9+,10-,11+,13-,14+;/m1./s1
• InChI key: SHQAYVXGAAXVHV-GNAIRZFJSA-M

Description

General description

Chondroitin, a glucosaminoglycan (GAG), is a polysaccharide chain of alternating units of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA) that can be sulfated on the either or both GalNAc and GlcA units. Chondroitin and its sulfates are frequently attached to proteins to form proteoglycans.[1]

Application

Chondroitin sulfate, a glucosaminoglycan (GAG) polysaccharide chain of alternating units of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA), is used in a wide variety of areas of research including bioengineering. Chondroitin sulfate may be used as a biomaterial copolymer or surface derivatization reagent in the development of drug delivery vehicles, tissue engineering devices and bioscaffolds. Chondroitin sulfate may be used for the development of biocompatible structures such as hydrogels, sponges, biofilms, microspheres and micelles.[2]

Biochem/physiol Actions

As a large, negatively charged, hydrophilic molecule that is too inflexible to fold into a compact globular structure, chondroitin sulfate molecules form porous hydrated gels, providing mechanical support to tissue and allowing rapid diffusion of water-soluble molecules and migration of cells.

Components

Chondroitin is an acidic mucopolysaccharide found in cartilage, skin, cornea, and umbilical cord. It is composed of alternating N-acetylgalactosamine, D-glucuronic acid, and sulfate residues in equimolar quantities that can be sulfated on either of its subunits. Sulfation can occur at the 6 and/or 4-position of the galactosamine moiety, with potential for any individual disaccharide unit to be 6-sulfated, 4-sulfated, 4,6-disulfated, or unsulfated.

Caution

Store this product at 2-8°C.

Preparation Note

This product is soluble in water at 100 mg/mL.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves