D7628

Dihydrouracil

powder

• Synonym(s): 5,6-Dihydro-2,4-dihydroxypyrimidine
• Empirical Formula (Hill Notation): C₄H₆N₂O₂
• CAS Number: 504-07-4
• Molecular Weight: 114.10
• EC Number: 207-982-1
• MDL number: MFCD00006029
• UNSPSC Code: 12352005
• PubChem Substance ID: 24894143
• NACRES: NA.21

Properties

• Quality Level: 100
• form: powder
• mp: 279-281 °C (lit.)
• SMILES string: O=C1CCNC(=O)N1
• InChI: 1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8)
• InChI key: OIVLITBTBDPEFK-UHFFFAOYSA-N

Description

General description

Dihydrouracil (DiHU) is a minor base found in transfer ribonucleic acid (tRNA). It is similar to uracil with the only exception that the C₅-C₆ bond is saturated. It crystallized in the monoclinic system with space group P2₁/_C. Its crystalline structure has been analyzed. Its generation from L-cysteine and uracil via photochemical addition has been described.

Application

Dihydrouracil has been used as a standard for ureido group in the colorimentric assay of transfer ribonucleic acid (tRNA).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves