E3263

Efaroxan hydrochloride

≥98% (HPLC)

• Synonym(s): 2-Ethyl-2-(imidazolin-2-yl)-2,3-dihydrobenzofuran hydrochloride, RX 821037A
• Empirical Formula (Hill Notation): C₁₃H₁₆N₂O · HCl
• CAS Number: 89197-00-2
• Molecular Weight: 252.74
• MDL number: MFCD00069270
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278415
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• solubility: H₂O: >20 mg/mL
• SMILES string: Cl.CCC1(Cc2ccccc2O1)C3=NCCN3
• InChI: 1S/C13H16N2O.ClH/c1-2-13(12-14-7-8-15-12)9-10-5-3-4-6-11(10)16-13;/h3-6H,2,7-9H2,1H3,(H,14,15);1H
• InChI key: DWOIUCRHVWIHAH-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Biochem/physiol Actions

(+)-Isomer is a selective α-adrenoceptor antagonist; (−)-isomer is an imidazoline ligand that induces insulin secretion, mediated by the blockade of ATP-sensitive potassium channels in pancreatic β cells; I₁ imidazoline binding site antagonist.

(+)-Isomer is a selective α-adrenoceptor antagonist; (−)-isomer is an imidazoline ligand; I₁ imidazoline binding site antagonist.

Features and Benefits

This compound is featured on the Imidazoline Binding Sites and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves