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G4535

Sigma-Aldrich

[D-Lys3]-GHRP-6

synthetic, lyophilized powder

Synonym(s):

[His1, D-Lys3, Lys6]-GHRP, His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2, [D-Lys3]-Growth Hormone Releasing Peptide 6

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100 μG
CA$442.00

About This Item

MDL number:
MFCD00214665
UNSPSC Code:
12352209
PubChem Substance ID:
329799930
NACRES:
NA.32

CA$442.00

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biological source

synthetic

Quality Level

200

form

lyophilized powder

UniProt accession no.

P01286

storage temp.

−20°C

SMILES string

NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H](N)Cc6c[nH]cn6)C(N)=O

InChI

1S/C49H63N13O6/c50-20-10-8-18-39(44(53)63)58-47(66)41(22-30-12-2-1-3-13-30)61-49(68)43(24-32-27-56-38-17-7-5-15-35(32)38)62-46(65)40(19-9-11-21-51)59-48(67)42(23-31-26-55-37-16-6-4-14-34(31)37)60-45(64)36(52)25-33-28-54-29-57-33/h1-7,12-17,26-29,36,39-43,55-56H,8-11,18-25,50-52H2,(H2,53,63)(H,54,57)(H,58,66)(H,59,67)(H,60,64)(H,61,68)(H,62,65)/t36-,39-,40+,41+,42+,43-/m0/s1

InChI key

MGSNWNLPMHXGDD-DFWOJPNQSA-N

Gene Information

human ... GHRH(2691)

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Corning® CoolRack® M30, capacity 30 x 1.5 or 2 mL microfuge tubes, gray

CLS432041

Corning® CoolRack®

Corning® CoolRack® M30, capacity 30 x 1.5 or 2 mL microfuge tubes, green

CLS432042

Corning® CoolRack®

feature

Holds 30 x 1.5 mL tubes

feature

Holds 30 x 0.5 mL tubes

feature

wells 30, Holds 30 x 1.5-2 mL tubes

feature

wells 31, Holds 30 x 1.5-2 mL tubes

manufacturer/tradename

Corning 432048

manufacturer/tradename

Corning 432046

manufacturer/tradename

Corning 432041

manufacturer/tradename

Corning 432042

material

foamed PE

material

foamed PE

material

foamed PE

material

foamed PE

packaging

pkg of 1

packaging

pkg of 1

packaging

pkg of 1

packaging

pkg of 1

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

color

gray

color

gray

color

gray

color

green

Amino Acid Sequence

His-Trp-Lys-Trp-Phe-Lys-NH2

General description

[D-Lys3]-GHRP6 (growth hormone releasing peptide 6) is a synthetic analog of the orexigenic peptide hormone called ghrelin.[1]

Application

[D-Lys3]-GHRP-6 has been used:
  • to study its role in incretin dysfunction and hyperglycemia in cystic fibrosis[2]
  • as an antagonist of growth hormone secretagogue receptor (GHS-R)[3]
  • as ghrelin receptor antagonist to study the dose-dependent effects of intraduodenal ghrelin on the glucose infusion rate (GIR) during pancreatic-euglycemic clamp procedure (PECs)[4]

[D-Lys3]-GHRP6 has been used-
  • to treat bovine somatotropes to determine the release of GH from treated cells and non-treated or control cells[1]
  • for intraperitoneal injection to groups of broiler chicken to determine the effect on feed intake, weight gain, and feed conversion ratio

Biochem/physiol Actions

[D-Lys3]-GHRP-6, a selective growth-hormone secretagogue receptor (GHSR) antagonist displays pro-autophagic effects on skeletal muscle. It can be used to study the dependency of GHSR-1a signalling mediated by acylated ghrelin.[5]
[D-Lys3]-GHRP6 (growth hormone releasing peptide 6) induces the secretion of growth hormone (GH). In the membrane of clonal GC somatotropes, this peptide elevates the number of functional voltage-gated Ca2+ and Na+ channels. Chronic treatment with this peptide causes an elevation in Na+ macroscopic current in bovine pituitary somatotropes in culture, which results in an increase in the release of GH.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCK4777
    SLCB8346
    SLBS0693V
    SLBR6794V
    SLBQ9847V

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