G6416
GW5074
powder
Synonym(s):
3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
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About This Item
Empirical Formula (Hill Notation):
C15H8Br2INO2
CAS Number:
Molecular Weight:
520.94
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Assay
≥98% (HPLC)
Quality Level
form
powder
storage condition
protect from light
color
yellow to orange-brown
solubility
DMSO: 5 mg/mL, clear
storage temp.
room temp
SMILES string
Oc1c(Br)cc(cc1Br)\C=C2/C(=O)Nc3ccc(I)cc23
InChI
1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChI key
LMXYVLFTZRPNRV-KMKOMSMNSA-N
Gene Information
human ... RAF1(5894)
Application
GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.
Biochem/physiol Actions
GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.
Other Notes
light sensitive
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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