GW21469

Anti-PTPRF antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Receptor-type tyrosine-protein phosphatase F
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: chicken
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, human, mouse
• manufacturer/tradename: Genway 15-288-21469
• technique(s): western blot: suitable
• NCBI accession no.: NP_002831.1
• UniProt accession no.: P10586
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PTPRF(5792)

Description

Immunogen

Immunogen Sequence: GI # 4506311, sequence 1151-1225

Recombinant protein tyrosine phosphatase, receptor type, F isoform 1

Application

Anti-PTPRF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Receptor-type tyrosine-protein phosphatase F is an enzyme encoded by the PTPRF gene in humans. It localizes to adherens junctions and may be involved in the regulation of epithelial cell-cell contacts, peptide growth factor signaling and the canonical Wnt pathway. PTPRF induction occurs by cell-cell contact during cell proliferation that activates ERK-dependent proliferation signaling to prevent cell hyperproliferation and tumor initiation. It acts as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin. PTPRF regulates cell proliferation, response to growth factors and cellular adhesion. Mutation in the gene is associated with breast cancer.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves