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Key Documents

H2167

Sigma-Aldrich

Histone H2B human

Synonym(s):

Histone, Human

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About This Item

CAS Number:
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human

Quality Level

recombinant

expressed in E. coli

form

liquid

concentration

1 mg/mL

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... H2BC1(255626)

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General description

Histones are highly basic chromatin proteins. They tightly organize eukaryotic DNA into nucleosomes. A nucleosome exists as an octameric core histone comprising a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B, wherein the 147 DNA base pairs are wrapped around the histone complex.

Application

Histone H2B human has been used in far western blot analysis.

Biochem/physiol Actions

Histones are known to regulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. Extrachromosomal histone H2B functions as a cytosolic sensor and detects the double-stranded DNA (dsDNA) fragments produced from infectious agents or damaged cells. This stimulates innate and acquired immune responses in different cell types. Histone H2B moves in and out of the nucleosome more quickly than other core histones.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Carc. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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