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H6916

Sigma-Aldrich

Macrophage Colony-Stimulating Factor human

≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

Synonym(s):

MCSF

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About This Item

MDL number:
MFCD00166591
UNSPSC Code:
12352202
NACRES:
NA.77

Product Name

Macrophage Colony-Stimulating Factor human, M-CSF, recombinant, expressed in HEK 293 cells, suitable for cell culture

biological source

human

Quality Level

100

recombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

≤4 ng/mL EC50

quality

endotoxin tested

mol wt

dimer 35-40 kDa (glycosylated)

packaging

pkg of 10 μg

manufacturer/tradename

HumanZyme

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P09603

storage temp.

−20°C

Gene Information

human ... CSF1(1435)

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General description

M-CSF is encoded by the gene mapped to human chromosome 1p13.3. It is a glycosylated polypeptide, which exists as a homodimer. M-CSF is produced by macrophage, fibroblasts, lymphocyte and endothelial cells.

Biochem/physiol Actions

Macrophage CSF (M-CSF) as a growth factor, stimulates the proliferation and differentiation of monocyte/macrophage-lineage cells. It also boosts antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages. In addition, human M-CSF inhibits bone resorption by osteoclasts. It might also play a crucial role in atherosclerosis. Overexpression of the gene has been observed in Paget′s disease of bone (PDB).

Physical form

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Analysis Note

The specific activity was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells (mouse myeloid Leukemia indicator cell line).

Legal Information

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ6857
MKCM2828
MKCK6161
MKCG7595
MKCF3913

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"Effects of macrophage colony-stimulating factor (M-CSF) on protease production from monocyte, macrophage and foam cell in vitro: a possible mechanism for anti-atherosclerotic effect of M-CSF.
Tojo N, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1452.3, 275-284 (1999)
Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.
Albagha O M E, et al.
Nature Genetics, 429(6), 520-520 (2010)
The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors.
Metcalf D.
Blood, 67(2), 257-267 (1986)
Human macrophage colony-stimulating factor inhibits bone resorption by osteoclasts disaggregated from rat bone.
Hattersley G, et al.
Journal of Cellular Physiology, 137(1), 199-203 (1988)
Macrophage colony-stimulating factor enhances monocyte and macrophage antibody-dependent cell-mediated cytotoxicity.
Mufson R A, et al.
Cellular Immunology, 119(1), 182-192 (1989)
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