I5403

Insulin-Like Growth Factor Binding Protein-2 human

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

• Synonym(s): IGFBP-2
• MDL number: MFCD02099094
• UNSPSC Code: 51111800
• NACRES: NA.32

Properties

• biological source: human
• Quality Level: 100
• recombinant: expressed in NSO cells
• Assay: ≥95% (SDS-PAGE)
• form: lyophilized powder
• potency: 0.04 μg/mL
• mol wt: ~36 kDa by SDS-PAGE; calculated mol wt ~31 kDa
• packaging: pkg of 25 μg
• storage condition: avoid repeated freeze/thaw cycles
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• UniProt accession no.: P18065
• storage temp.: −20°C
• Gene Information: human ... IGFBP2(3485)

Description

General description

The gene IGFBP-2 (insulin-like growth factor binding protein-2) is mapped to human chromosome 2q35.

Biochem/physiol Actions

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.

Exhibits a 2-10 fold higher affinity for IGF II than for IGF I.

IGFBP-2 (insulin-like growth factor binding protein-2) regulates the function of IGF ligands. IGFBP2 is associated with skeletal muscle cell proliferation and differentiation. It also plays an important role in the differentiation of corneal fibroblast.

Physical form

Lyophilized from a 0.2 μm filtered solution of 30% (v/v) acetonitrile with 0.1% (v/v) TFA

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319,H332
• Precautionary Statements: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves