J4137

JS-K

≥97%

• Synonym(s): O2-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate
• Empirical Formula (Hill Notation): C₁₃H₁₆N₆O₈
• CAS Number: 205432-12-8
• Molecular Weight: 384.30
• MDL number: MFCD06407868
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724519
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97%
• storage condition: desiccated
• solubility: DMSO: soluble 9.3 mg/mL; H₂O: insoluble
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CCOC(=O)N1CCN(CC1)\[N+]([O-])=N\Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O
• InChI: 1S/C13H16N6O8/c1-2-26-13(20)15-5-7-16(8-6-15)19(25)14-27-12-4-3-10(17(21)22)9-11(12)18(23)24/h3-4,9H,2,5-8H2,1H3/b19-14-
• InChI key: DNJRNBYZLPKSHV-RGEXLXHISA-N

Description

Biochem/physiol Actions

JS-K belongs to the class of diazeniumdiolate prodrug. It generates nitric oxide when metabolized by glutathione S-transferases (GST), which ensures optimal activity of JS-K. It has tumor growth inhibition action in human prostate cancer and leukemia.

Nitric oxide donor; antiproliferative.

Legal Information

Covered by US Patent No 6,610,660

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves