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Key Documents

K3268

Sigma-Aldrich

PAK7, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

KIAA1264, MGC26232, PAK5

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

product line

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

47-63 nmol/min·mg

mol wt

~130 kDa

UniProt accession no.

relevant disease(s)

cancer

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PAK7(57144)

Biochem/physiol Actions

PAK7 (p21 protein (Cdc42/Rac)-activated kinase 7) belongs to the group-2 PAKs and can activate JNK (Jun N-terminus kinase). It contain an amino-terminal CDC42 (cell division cycle 42)/RAC (AKT1, v-akt murine thymoma viral oncogene homolog 1) interactive domain and a carboxyl terminal kinase domain. It plays an important role in outgrowth of neuron cells and synaptic vesicle trafficking. In mice, absence of PAK7 and PAK6 causes learning and locomotion defects. It is mainly expressed in brain. However, it is also considered as an oncogene because of its expression in colorectal, esophageal and gastric cancers.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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