L0906

L-α-Lysophosphatidylcholine from Glycine max (soybean)

≥99%, lyophilized powder

• Synonym(s): 1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin
• CAS Number: 9008-30-4
• EC Number: 232-715-0
• MDL number: MFCD00131444
• UNSPSC Code: 51321705
• NACRES: NA.25

Properties

• biological source: soybean
• Quality Level: 200
• description: zwitterionic
• Assay: ≥99%
• form: lyophilized powder
• functional group: phospholipid
• lipid type: phosphoglycerides
• shipped in: ambient
• storage temp.: −20°C

Description

Biochem/physiol Actions

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun.

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na⁺ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K⁺ channels.

Packaging

Packaged under Argon.

Preparation Note

Prepared by the action of phospholipase A on soybean L-α-phosphatidylcholine (P 6263).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves