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Key Documents

L0906

Sigma-Aldrich

L-α-Lysophosphatidylcholine from Glycine max (soybean)

≥99%, lyophilized powder

Synonym(s):

1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC Code:
51321705
NACRES:
NA.25

biological source

soybean

Quality Level

description

zwitterionic

Assay

≥99%

form

lyophilized powder

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

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Biochem/physiol Actions

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun.
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.

Packaging

Packaged under Argon.

Preparation Note

Prepared by the action of phospholipase A on soybean L-α-phosphatidylcholine (P 6263).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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