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L135

Sigma-Aldrich

L-741,626

≥98% (HPLC)

Synonym(s):

(±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole

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About This Item

Empirical Formula (Hill Notation):
C20H21ClN2O
CAS Number:
81226-60-0
Molecular Weight:
340.85
MDL number:
MFCD00953632
UNSPSC Code:
12352200
PubChem Substance ID:
24278529
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥20 mg/mL
ethanol: 24 mg/mL
H2O: insoluble

storage temp.

room temp

SMILES string

OC1(CCN(CC1)Cc2c[nH]c3ccccc23)c4ccc(Cl)cc4

InChI

1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2

InChI key

LLBLNMUONVVVPG-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815)

Application

L-741,626 has been used as selective dopamine (D2) receptor antagonist to study its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells. It has also been used as a D2 receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release.

Biochem/physiol Actions

L-741,626 is a selective dopamine (D2) receptor antagonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
055M4613V
051M4617V
078K46152
078K46151
078K4615

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P Han et al.
Neuroscience, 158(4), 1699-1707 (2008-12-27)
Dopamine can modulate and excite spinal locomotor networks, affect afferent transmission and increase motoneuronal excitability. One of the mechanisms whereby dopamine increases motoneuronal excitability is to potentiate AMPA channel-mediated glutamatergic transmission onto motoneurons. However, it is not known which dopaminergic
Ferran Jardí et al.
Scientific reports, 8(1), 957-957 (2018-01-19)
Low testosterone (T) in men, especially its free fraction, has been associated with loss of energy. In accordance, orchidectomy (ORX) in rodents results in decreased physical activity. Still, the mechanisms through which T stimulates activity remain mostly obscure. Here, we
Smita Patel et al.
Neuropharmacology, 44(8), 1038-1046 (2003-05-24)
In the retina, activation of dopamine receptors, particularly the D2-like family (D2, D3, D4 receptor subtypes), with quinpirole suppresses the light sensitive cAMP pool and inhibits melatonin synthesis in photoreceptor cells. We have characterised rat retinal D4 receptors using the
F Chaperon et al.
Neuropharmacology, 44(8), 1047-1053 (2003-05-24)
The dopamine D(3) receptor agonist PD 128907 decreased body temperature in the rat. The selective dopamine D(3) and D(4) receptor antagonists, A-437203 and L-745,870, respectively, did not prevent this effect. In contrast, PD 128907-induced hypothermia was antagonized by SCH 23390
Naomi P Visanji et al.
Experimental neurology, 202(1), 85-92 (2006-07-04)
The role of D(3) receptors in the antiparkinsonian actions of l-DOPA and l-DOPA-induced dyskinesia (LID) remains unclear. The D(3) receptor partial agonist BP897 attenuates LID in primates without affecting the antiparkinsonian actions of l-DOPA, suggesting that "normalization" of D(3) activity
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