L5288

Latrunculin B

from Latruncula magnifica, ≥80% (HPLC), solid, actin polymerization inhibitor

• Synonym(s): LAT-B
• Empirical Formula (Hill Notation): C₂₀H₂₉NSO₅
• CAS Number: 76343-94-7
• Molecular Weight: 395.51
• MDL number: MFCD00270879
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817621
• NACRES: NA.77

Properties

• Product Name: Latrunculin B from Latruncula magnifica, ≥80% (HPLC), solid
• Quality Level: 200
• Assay: ≥80% (HPLC)
• form: solid
• mol wt: 395.5
• solubility: ethanol: soluble
• storage temp.: −20°C
• SMILES string: C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CCC=C1
• InChI: 1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
• InChI key: NSHPHXHGRHSMIK-JRIKCGFMSA-N

Description

General description

Latrunculin B is a macrocyclic toxin, which is produced by Latruncula magnifica.

Application

Latrunculin B from Latruncula magnifica has been used for actin depolymerisation in various experiments. It has also been used as a component in bone marrow-derived dendritic cell (BMDC) complete medium, to study the formation of tubules from phagosomes in dendritic cells.

Biochem/physiol Actions

Latrunculin B inhibits actin polymerization in vitro. Latrunculin B disrupts microfilament-mediated processes.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves