L9167

LWH-63 hydrochloride

≥98% (HPLC), solid

• Synonym(s): 4-(N-Ethyl-n-4-hydroxybutyl)amino-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidine hydrochloride, NIH-3
• Empirical Formula (Hill Notation): C₂₄H₃₅ClN₄O
• CAS Number: 276890-57-4
• Molecular Weight: 431.01
• MDL number: MFCD07784506
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724529
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: light brown
• solubility: DMSO: ~10 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Cl[H].CCN(CCCCO)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
• InChI: 1S/C24H34N4O.ClH/c1-8-27(11-9-10-12-29)23-21-18(5)19(6)28(24(21)26-20(7)25-23)22-16(3)13-15(2)14-17(22)4;/h13-14,29H,8-12H2,1-7H3;1H
• InChI key: DKVWSJKPRJIFPC-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Non-peptide CRF₁ corticotrophin-releasing factor antagonist.

Non-peptide CRF₁ corticotrophin-releasing factor antagonist. K_i = 0.68 nM; blocks ethanol-induced effects as well as CRF effects in mice, suggesting a possible therapeutic target for the treatment of stress-induced alcohol drinking.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves