M0319

MRS 2578

≥95% (HPLC)

• Synonym(s): 1,4-Di[3-(3-isothiocyanatophenyl)thioureido]butane
• Empirical Formula (Hill Notation): C₂₀H₂₀N₆S₄
• CAS Number: 711019-86-2
• Molecular Weight: 472.67
• MDL number: MFCD07370141
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724530
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white
• solubility: DMSO: >5 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: S=C=Nc1cccc(NC(=S)NCCCCNC(=S)Nc2cccc(c2)N=C=S)c1
• InChI: 1S/C20H20N6S4/c27-13-23-15-5-3-7-17(11-15)25-19(29)21-9-1-2-10-22-20(30)26-18-8-4-6-16(12-18)24-14-28/h3-8,11-12H,1-2,9-10H2,(H2,21,25,29)(H2,22,26,30)
• InChI key: QOHNRGHTJPFMSL-UHFFFAOYSA-N

Description

Application

MRS 2578 has been used an antagonist of purinoceptor P2Y6:

• to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
• in P. aeruginosa infected mice to test its effect on the inflammatory responses
• to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes

Biochem/physiol Actions

MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.

Potent and irreversible antagonist of P2Y₆ nucleotide receptor.

Features and Benefits

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301,H312 + H332,H315,H319,H334,H335
• Precautionary Statements: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves