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Key Documents

M5324

Sigma-Aldrich

PX 12

≥98% (HPLC), powder

Synonym(s):

2-[(1-methylpropyl)dithio]-1H-imidazole

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About This Item

Empirical Formula (Hill Notation):
C7H12N2S2
CAS Number:
Molecular Weight:
188.31
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

off-white to tan

solubility

DMSO: >25 mg/mL

storage temp.

2-8°C

SMILES string

CCC(C)SSc1ncc[nH]1

InChI

1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)

InChI key

BPBPYQWMFCTCNG-UHFFFAOYSA-N

Application

PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1α inhibitor to treat H2228 cells.

Biochem/physiol Actions

PX 12 is a thioredoxin inhibitor.
PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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