M9440

Methyl-3,4-dephostatin

>98% (HPLC), powder

• Synonym(s): 3,4-Dihydroxy-N-methyl-N-nitrosoaniline
• Empirical Formula (Hill Notation): C₇H₈N₂O₃
• CAS Number: 173043-84-0
• Molecular Weight: 168.15
• MDL number: MFCD01076450
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278575
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: >98% (HPLC)
• form: powder
• color: red-brown
• solubility: DMSO: soluble 18 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CN(N=O)c1ccc(O)c(O)c1
• InChI: 1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3
• InChI key: XAKAQCMEMMZUEO-UHFFFAOYSA-N
• Gene Information: human ... PTPN1(5770)

Description

Application

Methyl-3,4-dephostatin has been used as:

• an inhibitor for methyltransferases
• a kinase-related inhibitor for human transglutaminase
• a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein

Biochem/physiol Actions

Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).

Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves