P2254

Poly-L-proline

suitable for ligand binding assays, Mol wt 1,000-10,000

• Synonym(s): L-Proline homopolymer
• Empirical Formula (Hill Notation): C₅H₉NO₂
• CAS Number: 25191-13-3
• Molecular Weight: 115.13
• MDL number: MFCD00166364
• UNSPSC Code: 12352209
• PubChem Substance ID: 24898302
• NACRES: NA.26

Properties

• Product Name: Poly-L-proline, mol wt 1,000-10,000
• form: powder
• Quality Level: 200
• mol wt: 1,000-10,000
• technique(s): ligand binding assay: suitable
• color: white
• storage temp.: −20°C
• SMILES string: OC(=O)C1CCCN1
• InChI: 1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)
• InChI key: ONIBWKKTOPOVIA-UHFFFAOYSA-N

Description

Application

• Highly sensitive and selective electrochemical sensor for simultaneous determination of gallic acid, theophylline and caffeine using poly(l-proline) decorated carbon nanotubes in biological and food samples.: This study presents an innovative electrochemical sensor that utilizes poly-L-proline decorated carbon nanotubes for the simultaneous detection of gallic acid, theophylline, and caffeine. This sensor demonstrates high sensitivity and selectivity, making it suitable for applications in both biological and food samples (Aschemacher NA et al., 2024).


• Water-assisted and protein-initiated fast and controlled ring-opening polymerization of proline N-carboxyanhydride.: This research explores the water-assisted and protein-initiated ring-opening polymerization of proline N-carboxyanhydride, leading to the rapid and controlled synthesis of poly-L-proline. The study highlights the method′s efficiency and potential for producing high-quality poly-L-proline for various applications (Hu Y et al., 2022).


• Phosphorylation of the actin-binding protein profilin2a at S137 modulates bidirectional structural plasticity at dendritic spines.: This study examines the role of poly-L-proline regions in the actin-binding protein profilin2a, specifically focusing on its phosphorylation at S137. The findings reveal how these modifications impact the structural plasticity of dendritic spines, providing insights into neuronal function and plasticity (Cornelius J et al., 2023).


• A structural model of the profilin-formin pacemaker system for actin filament elongation.: This paper presents a structural model involving poly-L-proline regions within the profilin-formin complex, which acts as a pacemaker for actin filament elongation. The study offers a detailed understanding of the molecular mechanisms driving actin dynamics and cellular movement (Schutt CE et al., 2022).

Biochem/physiol Actions

Poly-L-Proline is an antigenic homopolymer.

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves