P4620

PD 146176

≥98% (HPLC), solid

• Synonym(s): 6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
• Empirical Formula (Hill Notation): C₁₅H₁₁NS
• CAS Number: 4079-26-9
• Molecular Weight: 237.32
• MDL number: MFCD05664738
• UNSPSC Code: 51111800
• PubChem Substance ID: 24724579
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: white to beige
• solubility: DMSO: soluble >10 mg/mL; H₂O: insoluble
• SMILES string: C1Sc2ccccc2-c3[nH]c4ccccc4c13
• InChI: 1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2
• InChI key: ZGOOPZVQMLHPFM-UHFFFAOYSA-N
• Gene Information: human ... ALOX15(246) ; mouse ... ALOX15(11687) ; rat ... ALOX15(81639)

Description

Application

PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.

Biochem/physiol Actions

15-Lipoxygenase inhibitor

PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves