P4651

Promethazine hydrochloride

• Synonym(s): 10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride
• Empirical Formula (Hill Notation): C₁₇H₂₀N₂S · HCl
• CAS Number: 58-33-3
• Molecular Weight: 320.88
• Beilstein: 4166397
• EC Number: 200-375-2
• MDL number: MFCD00012652
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277802
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 200
• originator: Wyeth
• storage temp.: 2-8°C
• SMILES string: Cl[H].CC(CN1c2ccccc2Sc3ccccc13)N(C)C
• InChI: 1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
• InChI key: XXPDBLUZJRXNNZ-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269)

Description

Biochem/physiol Actions

H₁ histamine receptor antagonist; CNS depressant; anticholinergic.

Features and Benefits

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Solubility: Freely soluble in water, in hot dehydrated alcohol and in Chloroform. Practically insoluble in ether, in acetone and in ethyl acetate.

Physical form

Appearance: White or faint yellow, odorless, Crystalline powder, slowly oxidizes and acquires a blue color, on prolonged exposure to air.

Safety Information

• Pictograms: GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H302,H317,H318,H411
• Precautionary Statements: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves