P5248

Etidronate disodium hydrate

≥97% (NMR), solid

• Synonym(s): Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
• Empirical Formula (Hill Notation): C₂H₆Na₂O₇P₂ · xH₂O
• CAS Number: 7414-83-7
• Molecular Weight: 249.99 (anhydrous basis)
• EC Number: 231-025-7
• MDL number: MFCD00152567
• UNSPSC Code: 12352200
• PubChem Substance ID: 329820220
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (NMR)
• form: solid
• color: white
• mp: >300 °C
• solubility: H₂O: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: [Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
• InChI: 1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
• InChI key: GWBBVOVXJZATQQ-UHFFFAOYSA-L

Description

Application

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).

Biochem/physiol Actions

Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC₅₀ = 80 μM) as compared to the nitrogen containing bisphosphonates

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves