P6402

Perphenazine

• Synonym(s): 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
• Empirical Formula (Hill Notation): C₂₁H₂₆ClN₃OS
• CAS Number: 58-39-9
• Molecular Weight: 403.97
• EC Number: 200-381-5
• MDL number: MFCD00056798
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278642
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 200
• originator: Schering Plough
• storage temp.: 2-8°C
• SMILES string: ClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
• InChI: 1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
• InChI key: RGCVKNLCSQQDEP-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), OPRS1(10280)

Description

General description

Perphenazine is an antipsychotic drug used in treating schizophrenia. It modulates antioxidant levels and helps in the management of oxidative injury in schizophrenia. However, it is less effective than the clozapine drug group in improving response to oxidative injury.

Biochem/physiol Actions

D₂ dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H317
• Precautionary Statements: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3