PZ0143

PF-4708671

≥98% (HPLC)

• Synonym(s): 2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole
• Empirical Formula (Hill Notation): C₁₉H₂₁F₃N₆
• CAS Number: 1255517-76-0
• Molecular Weight: 390.41
• MDL number: MFCD18086922
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823728
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: off-white
• solubility: DMSO: ≥20 mg/mL
• storage temp.: room temp
• SMILES string: CCC(C=NC=N1)=C1N2CCN(CC3=NC4=C(C=CC(C(F)(F)F)=C4)N3)CC2
• InChI: 1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)
• InChI key: FBLPQCAQRNSVHB-UHFFFAOYSA-N
• Gene Information: human ... RPS6KB1(6198) ; mouse ... Rps6kb1(72508) ; rat ... Rps6kb1(83840)

Description

Biochem/physiol Actions

PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor.

PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC₅₀ of 160 nM, while having no effect on the closely related RSK and MSK kinases.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable