PZ0196

Tenidap

≥97% (HPLC)

• Synonym(s): (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide, CP 66248
• Empirical Formula (Hill Notation): C₁₄H₉ClN₂O₃S
• CAS Number: 120210-48-2
• Molecular Weight: 320.75
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: powder
• color: faintly yellow to dark yellow
• solubility: DMSO: 1 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: [s]1c(ccc1)C(=O)c2c3c([n](c2O)C(=O)N)ccc(c3)Cl
• InChI: 1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20)
• InChI key: IZSFDUMVCVVWKW-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Tenidap is an anti-inflammatory and anti-rheumatic with a variety of activities. Tenidap preferentially inhibits COX-1 with an IC₅₀ value of 30 nM, and also has some lesser inhibitory activity towards COX-2 and 5-lipoxygenase (IC₅₀ values are 1.2 and > 30 μM for COX-2 and 5-lipoxygenase respectively). Tenidap is also a cytokine modulator, an opener of inward rectifying hKIR2.3 channels (EC₅₀ = 402 nM) and has been shown to modulate cytoplasmic pH and inhibit anion transport in vitro.

Tenidap is an anti-inflammatory, anti-rheumatic and cytokine modulator.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable