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RAB0244

Sigma-Aldrich

Human IL-10 ELISA Kit

Synonym(s):

IL-10, Interleukin-10

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32
Pricing and availability is not currently available.
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species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
capture ELISA: suitable

input

sample type serum
sample type cell culture supernatant(s)
sample type plasma

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL10(3586)

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Human IL-10 ELISA Kit

RAB0244

Human IL-10 ELISA Kit

Human IL-10 ELISA Kit (for Lysates) for cell and tissue lysate samples

RAB1060

Human IL-10 ELISA Kit (for Lysates)

Mouse IL-10 ELISA Kit for serum, plasma and cell culture supernatant

RAB0245

Mouse IL-10 ELISA Kit

Equine Interleukin-10 ELISA Kit for serum, plasma and cell culture supernatants

RAB0243

Equine Interleukin-10 ELISA Kit

Gene Information

human ... IL10(3586)

Gene Information

human ... IL10(3586)

Gene Information

mouse ... Il10(16153)

Gene Information

equine ... IL10(100034187)

species reactivity

human

species reactivity

human

species reactivity

mouse

species reactivity

equine

input

sample type serum
sample type cell culture supernatant(s)
sample type plasma

input

sample type tissue lysate
sample type cell lysate

input

sample type cell culture supernatant(s)
sample type serum
sample type plasma

input

sample type serum
sample type cell culture supernatant(s)
sample type plasma

detection method

colorimetric

detection method

colorimetric

detection method

colorimetric

detection method

colorimetric

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells and B cells.[1] Murine IL-10 is inactive on human cells.[2] The gene encoding this protein is localized on human chromosome 1q31-32.[3]

Immunogen

Recombinant Human IL-10

Application

For research use only. Not for use in diagnostic procedures.
Human IL-10 ELISA kit has been used for determining the levels of IL-10 in cell culture supernatant. [4][5]
Human IL-10 ELISA Kit has been used in enzyme-linked immunosorbent assay (ELISA) to detect interleukin-10 (IL-10) in the plasma of uremic patients undergoing hemodialysis (HD).[6]

Biochem/physiol Actions

IL-10 (interleukin 10) is an anti-inflammatory cytokine.[7] IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF (tumor necrosis factor)-α.[8] Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions.[9] Polymorphisms in the IL-10 gene are associated with higher risk of preeclampsia, ankylosing spondylitis, nasopharyngeal carcinoma and basal cell carcinoma.[10][11][12][13] Polymorphism in IL-10 at -1082A/G is associated with diabetic nephropathy.[7]

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)
  • RABSTOP3ELISA Stop Solution (Item I)
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
  • RABWASH420X Wash Buffer (Item B)

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0620J0145
    0621J0145
    0622J0145
    0602J0145
    0615J0145

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    IL-10: A Multifunctional Cytokine in Viral Infections
    Rojas J, et al.
    Journal of immunology research (2017)
    Identification of functional domains on human interleukin-10
    Gesser B, et al.
    Proceedings of the National Academy of Sciences of the USA, 94(26), 14620-14620 (1997)
    Imbalance of Th22/Treg cells causes microinflammation in uremic patients undergoing hemodialysis
    Ren T, et al.
    Bioscience Reports, 39(10), 866-866 (2019)
    TNF-a and IL10 polymorphisms interaction increases the risk of ankylosing spondylitis in Chinese Han population.
    Wang NG
    International Journal of Clinical and Experimental Pathology, 8(11), 15204-15209 (2015)
    Relationship between IL-10 gene -819C/T polymorphism and the risk of inflammatory bowel disease: a meta-analysis
    Haien Wu
    African Health Sciences, 16(3), 866-872 (2016)
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