S2064

SC-560

≥98% (HPLC)

• Synonym(s): 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethyl pyrazole
• Empirical Formula (Hill Notation): C₁₇H₁₂ON₂ClF₃
• CAS Number: 188817-13-2
• Molecular Weight: 352.74
• MDL number: MFCD02179214
• UNSPSC Code: 51111800
• PubChem Substance ID: 24278696
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• solubility: DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1)-n2nc(cc2-c3ccc(Cl)cc3)C(F)(F)F
• InChI: 1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
• InChI key: PQUGCKBLVKJMNT-UHFFFAOYSA-N
• Gene Information: human ... PTGS1(5742), PTGS2(5743)

Description

Application

SC-560 has been used as a cyclooxygenase-1 (COX-1) inhibitor to study its effects on prostaglandin E-2 (PGE2) signaling in ciliogenesis in zebrafish embryos. It has also been used as a selective inhibitor of COX-1 to study its role in PM10-induced endothelial dysfunction.

Biochem/physiol Actions

SC-560 (5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole) is a non-steroidal anti-inflammatory drug (NSAID). It is a lipophilic, diaryl heterocyclic compound. SC-560 acts as an effective antiviral agent against hepatitis C virus (HCV). It also has a potential to hinder prostaglandin E2 synthesis in neurons at nanomolar concentrations.

SC-560 belongs to the diaryl heterocycle class of cyclooxygenase (COX) inhibitors. It exhibits anti-tumor and anti-proliferative activities.

Selective cyclooxygenase-1 (COX-1) inhibitor, exhibiting 700-fold selectivity for COX-1 over COX-2.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves