S2816

SKF-83959 hydrobromide

≥98% (HPLC), solid

• Synonym(s): 6-Chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
• Empirical Formula (Hill Notation): C₁₈H₂₀NClO₂ · HBr
• CAS Number: 80751-85-5
• Molecular Weight: 398.72
• MDL number: MFCD03792727
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278699
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >20 mg/mL; H₂O: insoluble
• SMILES string: Br[H].CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c3cccc(C)c3
• InChI: 1S/C18H20ClNO2.BrH/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19;/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3;1H
• InChI key: FHYWNBUFNGHNCP-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812)

Description

Application

SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice.

Biochem/physiol Actions

D₁ dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo.

SKF-83959 is an atypical agonist of D₁ dopamine receptor and an allosteric modulator of σ-1 receptor on in brain and liver tissues. It has neuroprotective and anti-parkinsonian effects through selective activation of phosphoinositol-linked D₁ receptor and promotes migration of cultures astrocytes by ERK1/2 activation. In in vitro studies SKF-83959 exhibits antagonist activity against dopamine D₁ receptors coupled to adenylyl cyclase.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves