S8197
SMER28
>99% (HPLC), solid
Synonym(s):
6-Bromo-N-2-propenyl-4-quinazolinamine
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About This Item
Empirical Formula (Hill Notation):
C11H10BrN3
CAS Number:
Molecular Weight:
264.12
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Quality Level
Assay
>99% (HPLC)
form
solid
solubility
DMSO: >20 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
Brc1ccc2ncnc(NCC=C)c2c1
InChI
1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
InChI key
BCPOLXUSCUFDGE-UHFFFAOYSA-N
Application
SMER28 may be used in mTOR-mediated signaling studies.
Biochem/physiol Actions
SMER28 is a small molecule modulator of mammalian autophagy.
SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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