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SAB4700351

Sigma-Aldrich

Monoclonal Anti-IgE antibody produced in mouse

clone BE5, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-IGHE

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.
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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

BE5, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

1 mg/mL

technique(s)

flow cytometry: suitable

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Show Differences

1 of 4

This Item
BP12101604803PHR1734
vibrant-m

Y0000714

Ritonavir

vibrant-m

BP1210

Ritonavir

USP

1604803

Ritonavir

Ritonavir Pharmaceutical Secondary Standard; Certified Reference Material

PHR1734

Ritonavir

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

USP

manufacturer/tradename

-

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

format

neat

format

neat

format

neat

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

biological source

synthetic

biological source

-

biological source

synthetic

biological source

synthetic

agency

EP

agency

BP

agency

USP

agency

BP, EP, USP, traceable to Ph. Eur. Y0000714, traceable to USP 1604803

General description

Immunoglobulin E (IgE) is encoded by the gene mapped to human chromosome 14q32.33. IgE belongs to the immunoglobulin family and consists of epsilon(ε) heavy chain in the constant (C) region. IgE has a monomeric structure with an extra domain in the constant region.
The antibody BE5 reacts with human IgE; it recognizes an epitope different from the ones recognized by 4G7 and 4H10 antibodies to IgE.

Immunogen

Purified human IgE

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Immunoglobulin E (IgE) binds very tightly to Fc receptors on basophils and mast cells. Thus, it plays a major role in stimulating allergic reactions. Elevated expression of the gene has been associated with the development of hyper IgE Syndrome (HIES), hay fever, atopic skin diseases such as eczema, anaphylactic shock and IgE-myeloma. In addition, overexpression of IgE is also observed in allergy/asthma. Therefore, increased levels of serum IgE can be considered as a diagnosis for asthma. IgE expression is down-regulated in congenital agammaglobulinemia and hypogammaglobulinemia because of faulty metabolism or synthesis of immunoglobulins.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    529221
    523514
    522545
    521333
    518453

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