SAB6010005

Anti-phospho-MAPT (S404) antibody, clone 11H10, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• Synonym(s): Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau), MAPT, MAPTL MTBT1 TAU
• UNSPSC Code: 12352203

Properties

• recombinant: expressed in HEK 293 F cells
• Quality Level: 100
• conjugate: unconjugated
• antibody product type: primary antibodies
• clone: 11H10, recombinant monoclonal
• form: liquid
• mol wt: 150 kDa
• purified by: affinity chromatography
• species reactivity: human
• concentration: 0.4mg/ml
• technique(s): ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• isotype: IgG
• UniProt accession no.: P10636
• shipped in: wet ice
• storage temp.: -10 to -25°C
• target post-translational modification: phosphorylation (pSer404)

Description

General description

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Immunogen

A synthesized peptide derived from Human MAPT

Sequence

ST-pS-PS

Physical form

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage and Stability

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable