SML0084

IM-12

≥98% (HPLC)

• Synonym(s): 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
• Empirical Formula (Hill Notation): C₂₂H₂₀FN₃O₂
• CAS Number: 1129669-05-1
• Molecular Weight: 377.41
• MDL number: MFCD20527313
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825145
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: yellow-orange
• solubility: DMSO: ≥9 mg/mL
• storage temp.: 2-8°C
• SMILES string: CN1C(=O)C(NCCc2ccc(F)cc2)=C(C1=O)c3c(C)[nH]c4ccccc34
• InChI: 1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3
• InChI key: ZKJAZFUFPPSFCO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

GSK-3β inhibitor

IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. IM-12 significantly increased β-catenin levels. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation resulting in an increase of neuronal cells. It has an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable