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SML0173

Sigma-Aldrich

Reversan

≥98% (HPLC)

Synonym(s):

CBLC4H10, N-[3-(4-Morpholinyl)propyl]-5,7-diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C26H27N5O2
CAS Number:
313397-13-6
Molecular Weight:
441.52
MDL number:
MFCD01528184
UNSPSC Code:
12161501
PubChem Substance ID:
329825203
NACRES:
NA.77
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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

faintly yellow to yellow

solubility

DMSO: ≥8 mg/mL at ~60 °C

storage temp.

2-8°C

SMILES string

O=C(NCCCN1CCOCC1)c2cnn3c(cc(nc23)-c4ccccc4)-c5ccccc5

InChI

1S/C26H27N5O2/c32-26(27-12-7-13-30-14-16-33-17-15-30)22-19-28-31-24(21-10-5-2-6-11-21)18-23(29-25(22)31)20-8-3-1-4-9-20/h1-6,8-11,18-19H,7,12-17H2,(H,27,32)

InChI key

JTRXWCLQFAZHGP-UHFFFAOYSA-N

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Indomethacin United States Pharmacopeia (USP) Reference Standard

1341001

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Indomethacin European Pharmacopoeia (EP) Reference Standard

I0200000

Indomethacin

Indomethacin Pharmaceutical Secondary Standard; Certified Reference Material

PHR1247

Indomethacin

Indomethacin 98.5-100.5% (in accordance with EP)

I7378

Indomethacin

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

-

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

-

format

neat

format

neat

format

neat

format

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

API family

indomethacin

API family

indomethacin

API family

indomethacin

API family

-

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Gene Information

human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224)
rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)

Application

Reversan may be used in cell signaling studies.

Biochem/physiol Actions

Nontoxic MRP1 function inhibitor; MRP1 and Pgp function inhibitor; multidrug transporter inhibitor
Reversan increases the efficacy of vincristine and etoposide and increases the sensitivity of murine models of neuroblastoma to conventional chemotherapy.[1][2]
Reversan is a selective and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp) inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    101M4615V

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