SML0376

CGS 9895

≥98% (HPLC)

• Synonym(s): 2,5-Dihydro-2-(4-methoxyphenyl)-3H-pyrazolo[4,3-c]quinolin-3-one, NSC 373970
• Empirical Formula (Hill Notation): C₁₇H₁₃N₃O₂
• CAS Number: 77779-50-1
• Molecular Weight: 291.30
• MDL number: MFCD23704790
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825377
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: light yellow to light brown
• solubility: DMSO: >2 mg/mL (warmed)
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1)N2N=C3C(=CNc4ccccc34)C2=O
• InChI: 1S/C17H13N3O2/c1-22-12-8-6-11(7-9-12)20-17(21)14-10-18-15-5-3-2-4-13(15)16(14)19-20/h2-10,18H,1H3
• InChI key: KSKRJZMRHSNRBX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CGS 9895 is a GABA antagonist that acts via the benzodiazepine binding site of ag containing GABA receptors. CGS 9895 is the only known compound that can specifically enhance GABA-induced currents in ab subunit containing receptors, and acts at the extracellular a1+b3- subunit interface.

CGS 9895 is a GABA antagonist; GABAA receptor selective enhancer.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable