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Key Documents

SML0525

Sigma-Aldrich

kb-NB142-70

≥97% (HPLC)

Synonym(s):

3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one

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About This Item

Empirical Formula (Hill Notation):
C11H9NO2S2
CAS Number:
Molecular Weight:
251.32
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

Oc1ccc2sc3C(=O)NCCSc3c2c1

InChI

1S/C11H9NO2S2/c13-6-1-2-8-7(5-6)9-10(16-8)11(14)12-3-4-15-9/h1-2,5,13H,3-4H2,(H,12,14)

InChI key

DHUAGGSHTKPOHU-UHFFFAOYSA-N

Biochem/physiol Actions

kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673, with approximately 6-fold greater potency (IC50 for inhibition of PKD1 = 28.3 nM vs. 182 nM for CID755673). kb-NB142-70 dose dependently inhibits proliferation of PC3 prostate cancer cell, and blocks migration of the prostate cancer lines PC3 and DU145.
kb-NB142-70 is a protein kinase D (PKD1) inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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