SML0525

kb-NB142-70

≥97% (HPLC)

• Synonym(s): 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one
• Empirical Formula (Hill Notation): C₁₁H₉NO₂S₂
• CAS Number: 1233533-04-4
• Molecular Weight: 251.32
• MDL number: MFCD18086915
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825531
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Oc1ccc2sc3C(=O)NCCSc3c2c1
• InChI: 1S/C11H9NO2S2/c13-6-1-2-8-7(5-6)9-10(16-8)11(14)12-3-4-15-9/h1-2,5,13H,3-4H2,(H,12,14)
• InChI key: DHUAGGSHTKPOHU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673, with approximately 6-fold greater potency (IC₅₀ for inhibition of PKD1 = 28.3 nM vs. 182 nM for CID755673). kb-NB142-70 dose dependently inhibits proliferation of PC3 prostate cancer cell, and blocks migration of the prostate cancer lines PC3 and DU145.

kb-NB142-70 is a protein kinase D (PKD1) inhibitor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable