SML0796

HI-TOPK-032

≥98% (HPLC)

• Synonym(s): N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide
• Empirical Formula (Hill Notation): C₂₀H₁₁N₅OS
• CAS Number: 487020-03-1
• Molecular Weight: 369.40
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: orange to dark red
• solubility: DMSO: 3 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: [s]1c(ccc1)C(=O)Nc2cc3[n](c4nc5c(nc4c3C#N)cccc5)cc2
• InChI: 1S/C20H11N5OS/c21-11-13-16-10-12(22-20(26)17-6-3-9-27-17)7-8-25(16)19-18(13)23-14-4-1-2-5-15(14)24-19/h1-10H,(H,22,26)
• InChI key: BCSBXWKRZUPFHW-UHFFFAOYSA-N

Description

Application

HI-TOPK-032 has been used as a PDZ binding-kinase (PBK) inhibitor.

Biochem/physiol Actions

HI-TOPK-032 belongs to the class of ATP-competitive inhibitors. It can also be used as a potent therapeutic for colorectal cancer.

HI-TOPK-032 is a specific TOPK (T-LAK cell–originated protein kinase) inhibitor both in vitro and in vivo. HI-TOPK-032 suppressed tumor growth in a colon cancer xenograft model.

HI-TOPK-032 is a specific TOPK inhibitor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable