SML1317

XAP044

≥98% (HPLC)

• Synonym(s): 7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one, XAP 044
• Empirical Formula (Hill Notation): C₁₅H₉IO₄
• CAS Number: 196928-50-4
• Molecular Weight: 380.13
• MDL number: MFCD00525548
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825781
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3
• InChI: 1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
• InChI key: XXZKJJYWINSUMJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

XAP044 is a brain penetrant, potent and selective mGlu7 (metabotropic glutamate receptor subtype 7) antagonist that inhibits lateral amygdala long-term potentiation (LTP) in brain slices from wild type mice. XAP044 binds to a pocket localized in mGlu7′s extracellular Venus flytrap domain (VFTD) close to the binding site of the orthosteric agonist L-glutamate. XAP044 exhibits a wide-spectrum anti-stress, antidepressant- and anxiolytic-like efficacy in rodent behavioral model.

XAP044 is a brain penetrant, potent and selective mGlu7 antagonist.

Other Notes

Light sensitive. This compound has Iodine and should be kept in the dark.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable