SML1352

CINK4

≥95% (HPLC)

• Synonym(s): trans-4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-cyclohexanol
• Empirical Formula (Hill Notation): C₂₇H₃₂N₆O
• CAS Number: 359886-84-3
• Molecular Weight: 456.58
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825807
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 25 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O[C@@H]1CC[C@@H](NC2=CC(NCC)=NC(NC3=CC=C(N(CC4=CC=CC=C4)C=C5)C5=C3)=N2)CC1
• InChI: 1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,18H2,1H3,(H3,28,29,30,31,32)/t21-,23-
• InChI key: YVXCDLCJCIDFHE-AFARHQOCSA-N

Description

Biochem/physiol Actions

CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes (IC₅₀ = 1.5 mM). CINK4 has greater than 50 fold selectivity over CDK1 or CDK2. CINK4 dose-dependently inhibits phosphorylation of retinoblastoma (Rb) and induces G0-G1 cell cycle arrest and apoptosis in cancer cell lines.

CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable