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SML1366

Sigma-Aldrich

CVT-10216

≥98% (HPLC)

Synonym(s):

3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]-benzoic acid, 3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-chromen-7-yl]oxy]methyl]benzoic acid, CVT 10216, GS 455534

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5 MG
₹12,749.00
25 MG
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About This Item

Empirical Formula (Hill Notation):
C24H19NO7S
CAS Number:
1005334-57-5
Molecular Weight:
465.48
MDL number:
MFCD18072197
UNSPSC Code:
12352200
PubChem Substance ID:
329825820
NACRES:
NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(O)C1=CC(COC2=CC=C3C(OC=C(C4=CC=C(NS(C)(=O)=O)C=C4)C3=O)=C2)=CC=C1

InChI

1S/C24H19NO7S/c1-33(29,30)25-18-7-5-16(6-8-18)21-14-32-22-12-19(9-10-20(22)23(21)26)31-13-15-3-2-4-17(11-15)24(27)28/h2-12,14,25H,13H2,1H3,(H,27,28)

InChI key

YYOOFJZTRCPVFD-UHFFFAOYSA-N

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Show Differences

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This Item
SML1915SML1799SML1179
CVT-10216 ≥98% (HPLC)

SML1366

CVT-10216

T-26c ≥98% (HPLC)

SML1915

T-26c

UCPH-102 ≥98% (HPLC)

SML1799

UCPH-102

WWL113 ≥98% (HPLC)

SML1179

WWL113

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

General description

CVT-10216 is a 5-HT2c agonist.[1]

Biochem/physiol Actions

CVT-10216 is a selective reversible inhibitor of aldehyde dehydrogenase-2 (ALDH-2), thereby inhibiting dopamine synthesis. CVT-10216 is active in suppressing alcohol and cocaine use, and anxiety.
CVT-10216 is a selective reversible inhibitor of aldehyde dehydrogenase-2.
CVT-10216 possesses unequivocal anxiolytic properties. It will not affect the suppression of locomotor activity by mCPP (m-chlorophenylpiperazine).[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    095M4613V

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    David H Overstreet et al.
    Pharmacology, biochemistry, and behavior, 94(2), 255-261 (2009-09-15)
    CVT-10216 is a highly selective, reversible inhibitor of ALDH-2 that reduces excessive alcohol drinking. Anxiety plays a role in alcoholism. The present study asks whether CVT-10216 has anxiolytic properties, as reflected in social interaction behavior in four unrelated rodent models:
    Bin Yuan et al.
    PloS one, 15(11), e0242809-e0242809 (2020-12-01)
    The bone marrow microenvironment (BME) in acute myeloid leukemia (AML) consists of various cell types that support the growth of AML cells and protect them from chemotherapy. Mesenchymal stromal cells (MSCs) in the BME have been shown to contribute immensely
    Simin Zhang et al.
    Aesthetic plastic surgery, 44(3), 993-1005 (2020-01-19)
    The cutaneous wound healing process mainly comprises re-epithelialization, fibrosis, and neovascularization. Impaired wound healing is common but tricky in plastic surgery. Aldehyde dehydrogenase 2 (ALDH2), the most effective subset of the ALDH enzyme family, is known to exert a major

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