SML1893

RO5256390

≥98% (HPLC)

• Synonym(s): (S)-4-((S)-2-phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine
• Empirical Formula (Hill Notation): C₁₃H₁₈N₂O
• CAS Number: 1043495-96-0
• Molecular Weight: 218.29
• MDL number: MFCD28405494
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D 14 to 19°, c = 1 in methanol
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC[C@@H](C[C@H]1COC(N)=N1)C2=CC=CC=C2
• InChI: 1S/C13H18N2O/c1-2-10(11-6-4-3-5-7-11)8-12-9-16-13(14)15-12/h3-7,10,12H,2,8-9H2,1H3,(H2,14,15)/t10-,12-/m0/s1
• InChI key: IXDKFUBXESWHSL-JQWIXIFHSA-N

Description

Biochem/physiol Actions

RO5256390 is an agonist of Trace amine-associated receptor 1 (TAAR1), a GPCR primarily found in the brain, expressed in areas where the major monoamine amine transmitters (DA and NE) are also present. RO5256390 is a selective TAAR1 agonist shown to be a negative regulator of dopamine transmission. It has antipsychotic activity in models of schizophrenia, reduces cocaine′s reinforcng effects, and blocks binge-eating disorder.

TAAR1 agonist

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable