SML2113

FR194921

≥98% (HPLC)

• Synonym(s): 2-(1-Methyl-4-piperidinyl)-6-[2-phenylpyrazolo-(1,5-a)pyridin-3-yl]-3(2H)-pyridazinone
• Empirical Formula (Hill Notation): C₂₃H₂₃N₅O
• CAS Number: 202646-80-8
• Molecular Weight: 385.46
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: CN(CC1)CCC1N2N=C(C=CC2=O)C3=C4N(N=C3C5=CC=CC=C5)C=CC=C4
• InChI: 1S/C23H23N5O/c1-26-15-12-18(13-16-26)28-21(29)11-10-19(24-28)22-20-9-5-6-14-27(20)25-23(22)17-7-3-2-4-8-17/h2-11,14,18H,12-13,15-16H2,1H3
• InChI key: YHDRUTMZCJZJAL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

A1R adenosine receptor antagonist

FR194921 is a blood-brain barrier-permeable A1R adenosine receptor antagonist. The measured Ki values of FR194921 for the human adenosine A1 receptors have been in the low nM range with no binding affinity for A2A and A3 receptors up to 1μM. It is orally active and has good bioavailability. FR194921 was used in a recent study to restore auditory cortex plasticity. Paired with sound exposure, FR194921 resulted in cortical map plasticity and improved auditory perception in adult mice.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3