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SML2227

Sigma-Aldrich

Emricasan

≥98% (HPLC), powder, pan-caspase inhibitor

Synonym(s):

IDN-6556, N-[2-(1,1-dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-Alaninamide, PF-03491390

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CA$32.00

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About This Item

Empirical Formula (Hill Notation):
C26H27F4N3O7
CAS Number:
Molecular Weight:
569.50
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

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Product Name

Emricasan, ≥98% (HPLC)

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC(C)(C)C1=C(NC(C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(COC2=C(F)C(F)=CC(F)=C2F)=O)=O)=O)=O)C=CC=C1

InChI

1S/C26H27F4N3O7/c1-12(31-24(38)25(39)32-16-8-6-5-7-13(16)26(2,3)4)23(37)33-17(10-19(35)36)18(34)11-40-22-20(29)14(27)9-15(28)21(22)30/h5-9,12,17H,10-11H2,1-4H3,(H,31,38)(H,32,39)(H,33,37)(H,35,36)/t12-,17-/m0/s1

InChI key

SCVHJVCATBPIHN-SJCJKPOMSA-N

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This Item
HPA048598SAB1300929MABN2268
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

saturated ammonium sulfate (SAS) precipitated

antibody form

purified immunoglobulin

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

shipped in

ambient

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

12F2.1, monoclonal

Biochem/physiol Actions

Antiapoptotic caspase inhibitor; Pan-Caspase Inhibitor
Emricasan is an antiapoptotic pan-caspase inhibitor. It has been in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) with advanced fibrosis (scarring) and cirrhosis. Emricasan has also been shown to protect infected astrocytes from ZIKV-induced cell death.
Emricasan, formerly known as IDN-6556, in combination with birinapan is used to treat acute myeloid leukemia (AML).[1] This small molecule irreversible inhibitor is under clinical investigation to reduce hepatic injury and liver fibrosis.[2]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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