SML2247

1G244

≥98% (HPLC)

• Synonym(s): (2S)- 2-Amino-4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-1-(1,3-dihydro-2H-isoindol-2-yl)-1,4-butanedione, 2-[(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-1,4-dioxobutyl]-2,3-dihydro-1H-isoindole, PTX 1210
• Empirical Formula (Hill Notation): C₂₉H₃₀F₂N₄O₂
• CAS Number: 847928-32-9
• Molecular Weight: 504.57
• MDL number: MFCD30489564
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C[C@@H](C(N1CC(C=CC=C2)=C2C1)=O)N)N3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3
• InChI: 1S/C29H30F2N4O2/c30-24-9-5-20(6-10-24)28(21-7-11-25(31)12-8-21)34-15-13-33(14-16-34)27(36)17-26(32)29(37)35-18-22-3-1-2-4-23(22)19-35/h1-12,26,28H,13-19,32H2/t26-/m0/s1
• InChI key: ZKIQFLSGMMYCGS-SANMLTNESA-N

Description

Biochem/physiol Actions

1G244 is a cell penetrant, highly potent and specific inhibitor of dipeptidyl peptidase 8 (DPP8) and DPP9. 1G244 is a slow-tight binding competitive inhibitor of DPP8, but it is a competitive and reversible inhibitor of DPP9.

1G244 is known to exhibit in vitro anti-myeloma actions. It might be involved in inducing pyroptotic cell death without ASC (apoptosis-associated speck-like protein containing a CARD) or interleukin (IL)-1 cleavage in human macrophage-like cells.

cell penetrant, highly potent and specific DPP8/9 inhibitor

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable