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SML2395

Sigma-Aldrich

Elocalcitol

≥98% (HPLC)

Synonym(s):

(1R,3Z,5S)-3-[(2E)-2-[(3aS,7aS)-1-[(1S,3E)-5-ethyl-5-hydroxy-1-methyl-3-hepten-1-yl]-3,3a,5,6,7,7a-hexahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylenecyclohexanol, BXL 628, BXL-628, Ro 26-9228

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5 G
MYR 395.00

About This Item

Empirical Formula (Hill Notation):
C29H43FO2
CAS Number:
199798-84-0
Molecular Weight:
442.65
MDL number:
MFCD09954119
UNSPSC Code:
12352200

MYR 395.00

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Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +97 to +107°, c = c=1 in methanol

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

F[C@H]1C[C@@H](C\C(=C\C=C2\[C@H]3[C@](CCC\2)(C(=CC3)[C@H](C\C=C\C(O)(CC)CC)C)C)\C1=C)O

InChI

1S/C29H43FO2/c1-6-29(32,7-2)17-8-10-20(3)25-14-15-26-22(11-9-16-28(25,26)5)12-13-23-18-24(31)19-27(30)21(23)4/h8,12-14,17,20,24,26-27,31-32H,4,6-7,9-11,15-16,18-19H2,1-3,5H3/b17-8+,22-12+,23-13-/t20-,24+,26-,27-,28+/m0/s1

InChI key

LRLWXBHFPGSUOX-GJQYOBCGSA-N

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biological source

bovine milk

biological source

bovine milk

biological source

bovine milk

biological source

bovine milk

technique(s)

electrophoresis: suitable

technique(s)

microbiological culture: suitable

technique(s)

cell culture | mammalian: suitable, electrophoresis: suitable

technique(s)

indirect ELISA: suitable

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

300

form

powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

Gene Information

cow ... LALBA(281894)

Gene Information

cow ... LALBA(281894)

Gene Information

cow ... LALBA(281894)

Gene Information

cow ... LALBA(281894)

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Biochem/physiol Actions

Elocalcitol (BX-L628) is an analog of Vitamin D3 that acts as an agonist at vitamin D VDR receptors. It has been shown to inhibit prostate cell growth and RhoA/Rho-kinase signaling. Elocalcitol (BXL-628) downregulated the expression of active RhoA and ROCK activity induced by high glucose and was shown to have renal protective effects.
Elocalcitol is a Vitamin D receptor (VDR) agonist and is an analog of calcitriol.[1][2] Elocalcitol possesses anti-inflammatory and anti- proliferative properties.[1] It regulates cell apoptosis and cell proliferation by binding to Vitamin D receptors (VDR).[3] It shows a therapeutic effect on people suffering from Benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS).[2]
Vitamin D3 analog

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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