SML2634

QX77

≥98% (HPLC)

• Synonym(s): N-(4-(7-Chloro-2H-benzo[b][1,4]oxazin-3-yl)phenyl)acetamide, N-[4-(7-Chloro-2H-1,4-benzoxazin-3-yl)phenyl]acetamide, QX 77, QX-77
• Empirical Formula (Hill Notation): C₁₆H₁₃ClN₂O₂
• CAS Number: 1798331-92-6
• Molecular Weight: 300.74
• MDL number: MFCD31657441
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Clc1cc2c(cc1)NC(=CO2)c3ccc(cc3)NC(=O)C
• InChI: 1S/C16H13ClN2O2/c1-10(20)18-13-5-2-11(3-6-13)15-9-21-16-8-12(17)4-7-14(16)19-15/h2-9,19H,1H3,(H,18,20)
• InChI key: FVNBPTNXXWCRJJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Chaperone-mediated autophagy (CMA) activator that rescues LAMP2A lysosomal localization in cystinotic cells and reduces toxic α-syn accumulation in PD astrocytes.

QX77 is a chaperone-mediated autophagy (CMA) activator derived from the atypical retinoid AR7 that activates CMA by antagonizing retinoic acid receptor-α (RARα) signaling. QX77 rescues defective trafficking & lysosomal localization of the CMA receptor LAMP2A in cystinotic Ctns^-/- MEFs and CTNS-KO human proximal tubule cells (PTCs) by restoring Rab11 expression and Rab11-positive vesicles trafficking to the level seen in wild-type cells (20 μM, 48 hrs). CMA activation by QX77 treatment (20 μM, 5 days) also significantly reduces toxic α-synuclein (α-syn) accumulation in PD patients iPSCs-derived astrocytes with LRRK2 G2019S mutation.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable