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SML2675

Sigma-Aldrich

CuET

≥97% (HPLC)

Synonym(s):

Copper bis(N,N-diethyldithiocarbamate), Cupric diethyldithiocarbamate, Merkupral, NSC 177697, bis(N,N-Diethyldithiocarbamato)copper(II)

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About This Item

Empirical Formula (Hill Notation):
C10H20CuN2S4
CAS Number:
13681-87-3
Molecular Weight:
360.09
MDL number:
MFCD00070506
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

dark green to black

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CCN(CC)C(S[Cu]SC(N(CC)CC)=S)=S

InChI

1S/2C5H11NS2.Cu/c2*1-3-6(4-2)5(7)8;/h2*3-4H2,1-2H3,(H,7,8);/q;;+2/p-2

InChI key

OBBCYCYCTJQCCK-UHFFFAOYSA-L

Biochem/physiol Actions

CuET, a metabolite of disulfiram, is an inhibitor of p97 segregase adaptor NPL4 that exhibits potent anti-cancer effects. Apparently CuET binds NPL4 and induces its aggregation, which disables the vital p97–NPL4–UFD1 pathway and induces to cell death.
Inhibitor of NPL4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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