SML3289

Synucleozid dihydrochloride

≥98% (HPLC)

• Synonym(s): 2-(4-(4-Carbamimidoylphenylamino)phenyl)-1H-indole-6-carboximidamide, dihydrochloride, 2-[4-(4-Carbamimidoylanilino)phenyl]-1H-indole-6-carboximidamide, dihydrochloride, 2-[4-[[4-(Aminoiminomethyl)phenyl]amino]phenyl]-1H-indole-6-carboximidamide, dihydrochloride, NSC 377363 2HCl, NSC-377363 2HCl, NSC377363 2HCl
• Empirical Formula (Hill Notation): C₂₂H₂₀N₆ · 2HCl
• Molecular Weight: 441.36
• MDL number: MFCD34470022
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: , White to very dark grey
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [nH]1c2c(cc1c3ccc(cc3)Nc4ccc(cc4)C(=N)N)ccc(c2)C(=N)N
• InChI: 1S/C22H20N6/c23-21(24)14-5-9-18(10-6-14)27-17-7-3-13(4-8-17)19-11-15-1-2-16(22(25)26)12-20(15)28-19/h1-12,27-28H,(H3,23,24)(H3,25,26)
• InChI key: TZRXNWCLKYWDNH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Selective α-synuclein (α-syn) translation inhibitor with cytoprotective efficacy against preformed α-syn fibrils (PFFs) in SH-SY5Y neuronal cultures.

Synucleozid is a selective α-synuclein (α-syn) translation inhibitor (46% & 69% α-syn downregulation post 48 h, respectively, with 0.5 or 1 μM Synucleozid) with cytoprotective efficacy against preformed α-synuclein fibrils (PFFs) in SH-SY5Y neuronal cultures (56% protection; 0.5 μM Synucleozid added 24 h prior to 48 h 50 μg/mL PFFs exposure). Synucleozid directly and selectively targets α-syn (SNCA) mRNA 5′ UTR at the iron-responsive element (IRE) site, effectively interfering with the polysomes assembly onto SNCA mRNA.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable