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SML3292

Sigma-Aldrich

8-nitro-Cgmp Sodium

≥98% (HPLC)

Synonym(s):

8-​Nitro-guanosine cyclic 3′,​5′-​(hydrogen phosphate) sodium, 8-Nitro-guanosine 3′,5′-cyclic monophosphate sodium

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About This Item

Empirical Formula (Hill Notation):
C10H10N6O9P · Na
Molecular Weight:
412.18
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

storage temp.

−20°C

SMILES string

O[C@@H]1[C@@H]([C@@H](CO2)O[C@H]1N3C([N+]([O-])=O)=NC4=C3N=C(NC4=O)N)OP2([O-])=O.[Na+]

Biochem/physiol Actions

8-nitro-cGMP is a second messenger of nitric oxide, which is involved in intracellular redox signaling. 8-nitro-cGMP is a potent inhibitor of tau aggregation. 8-nitro-cGMP induces S-guanylation of tau both in vitro and in tau overexpressed HEK293T cells, which inhibits heparin-induced tau aggregation.
potent inhibitor of tau aggregation; second messenger of nitric oxide

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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